阿里云

# 替换brew.git
cd "$(brew --repo)"
git remote set-url origin https://mirrors.aliyun.com/homebrew/brew.git
# 替换homebrew-core.git
cd "$(brew --repo)/Library/Taps/homebrew/homebrew-core"
git remote set-url origin https://mirrors.aliyun.com/homebrew/homebrew-core.git
# 刷新源
brew update

清华源

# 替换brew.git
cd "$(brew --repo)"
git remote set-url origin https://mirrors.tuna.tsinghua.edu.cn/git/homebrew/brew.git
# 替换homebrew-core.git
cd "$(brew --repo)/Library/Taps/homebrew/homebrew-core"
git remote set-url origin https://mirrors.tuna.tsinghua.edu.cn/git/homebrew/homebrew-core.git
# 刷新源
brew update

修改homebrew-bottles

中国科大

echo 'export HOMEBREW_BOTTLE_DOMAIN=https://mirrors.ustc.edu.cn/homebrew-bottles' >> ~/.zshrc
source ~/.zshrc
//应用生效:
brew update

清华大学

echo 'export HOMEBREW_BOTTLE_DOMAIN=https://mirrors.tuna.tsinghua.edu.cn/homebrew-bottles' >> ~/.zshrc
$ source ~/.zshrc
//应用生效:
brew update

备注：如果你之前折腾过不少导致你的Homebrew有点问题，那么可以尝试使用如下方案：

//诊断Homebrew的问题:
brew doctor
//重置brew.git设置:
cd "$(brew --repo)"
git fetch
git reset --hard origin/master
//homebrew-core.git同理:
cd "$(brew --repo)/Library/Taps/homebrew/homebrew-core"
git fetch
git reset --hard origin/master
//应用生效:
brew update  

重置更新源 某些时候也有换回官方源的需求

//重置brew.git:
cd "$(brew --repo)"
git remote set-url origin https://github.com/Homebrew/brew.git

//重置homebrew-core.git:
cd "$(brew --repo)/Library/Taps/homebrew/homebrew-core"
git remote set-url origin https://github.com/Homebrew/homebrew-core.git

后记

完成更新源的更换后，我们可以使用
brew upgrade将现有的软件进行更新至最新版本，这样便能很直接的看出速度上的变化了。最后不要忘记brew cleanup将旧有的软件安装包进行清理